This guide like the reset guarantees a win (read Overview if you disagree please) and Perfect Score of 5/5 if you follow it exactly, gather all DNA, adjust game time so you don't lose any DNA as it gets hectic after Transmission, and spend the DNA in the order I'll have listed for your convenience! Let's attach this pig's tail on humanity and see them lose themselves until we send em to the butcher!

Shall we begin?

Having tried a number of suggestions I still found ATP Boost beat out other options and while borders slow it down I had no need for Suppression allowing these genes to get the job done so you can both win and grab a perfect score (Read Overview Note).

• ATP Boost
  
  • While other genes were suggested they were too unpredictable and ATP Boost got us there quicker each time I tested in comparison and this is a must if we want to reach a win!
• Genetic Mimic
  
  • A gene that makes it harder to cure disease.
• Aquacyte
  
  • Greenland is ever the pain and we're going to want to snag it and/or Iceland asap.
• Urbophile
  
  • We've got a few Countries who's borders will slow us down. We'll want to prevent as many closed borders as possible by infecting Urban areas asap.
• Sympto-Stasis
  
  • We're going to win this by increasing our Prion's infectivity, severity, and lethality (timing on this last is important).

Saudi Arabia once again proves to do the trick (imho) better than the popular starting Countries like China or South Africa.

We want to boost Prion's Infectivity and Severity without spending too much DNA this early on but we also want it ready for Greenland, Iceland, Canada, Sweden, and others that may trouble us later.

• Rash
  
• Nausea
  
• Sweating
  
• Vomiting
  
• Cysts
  
• Hyper Sensitivity
  
  • Abscesses
    
  • Good for Wealthier Countries (Canada and others that are slow)
• Coughing
  
• Pneumonia
  
  • Good for Cold Weather Countries (Greenland and others that are slow)
• Sneezing

Keeping it simple to save on DNA and because anymore won't be needed with Symptoms doing a lot of the work.

• Water 1
  
• Air 1
  
• Water 2

IMPORTANT: At this point there are going to be numerous bubbles to pop and so I highly recommend slowing the game to 2 or 1 if you need but be careful because if you press the keys for game-speed (1, 2, or 3) when a pop-up is present the background un-pauses but the pop-up still blocks a portion of the view and if your mouse is moving when you try to click OK it often doesn't register.

We of course want to help spread the Prion across the globe but our focus is Greenland so some of these are obvious but slowing the cure's progress should be a goal as well.

• Cold Resistance 1
  
• Cold Resistance 2
  
  • This is important if we want to hit Greenland especially if the world grows colder event pops up.
• Heat Resistance 1
  
  • In the end if we're dealing with borders it will either be Sweden which we have covered or Monaco which this is one of the reasons for this ability but there is no need for lvl 2.
• Drug Resistance 1
  
• Drug Resistance 2
  
  • Vital for spreading in Wealthier areas who believe a couple Tylenol will do the trick... tricks on them.
• Genetic Hardening 1
  
• Genetic Hardening 2
  
  • This will significantly slow the progress of the cure especially with future Symptoms and Abilities to help.

We've gathered a good deal of DNA and want more while also making it even more difficult for those hoping for a cure that will never come!

• Pulmonary Odema
  
  • Helping boost DNA with severity, spreading the infection, and slightly raising the Lethality. All good things if you're a Prion!
• Skin Lesions
  
  Increases infectivity significantly and with both Skin Lesions and Pulmonary Odema in combination with all our symptoms should break all borders avoiding the need for the Suppression Gene and/or Bird 1.
• Insomnia
  
• Paranoia
  
• Seizures
  
• Paralysis
  
• Coma
  
  • The above five symptoms are useful for slowing and cutting progress of the cure back which allows us to further focus on improving our disease.

The scientists all over the globe have let their hubris step aside and are willing to cooperate with one another which is never a good thing but we've taken steps to slow them down... We're not done yet!

• Neural Atrophy 1
  
• Neural Atrophy 2
  
• Neural Atrophy 3
  
  • Killing off brain cells without the high makes complex tasks more difficult to complete which leads to further slowing the progress of the cure.

We've made great progress infecting most Countries but we still have a few who were better prepared and time and additional symptoms are required but we also wish to keep our cure down while we hit the point of no return (will go into detail near the end).

• Necrosis
  
  • Not only does this kill the host quickly (but not too quickly which is good) but leaves the corpse as a strong source for transmission.

• Genetic Reshuffle 1
  
  • We want to bring the progress and keep it below 30% preferably 20-25% so if you have spare DNA while enough to finish up our next few lethal Symptoms go ahead and evolve Genetic Reshuffle 2 though 3 may be too much a risk!

We should have all Countries infected at this point. Once our most recent Country hit's 15,000 infected and is spreading fast we can finally start doing some serious damage to end this quickly.

• Total Organ Failure
  
  • I repeat, wait for the last Country to reach 10-15k infected and growing in numbers quickly or you risk killing off all infected leaving uninfected which leads to a loss. This Symptom is going to do the most damage and do it quick!
• Dysentery
  
  • Helps spread infection while also increasing how lethal our disease is becoming. You'll need to evolve either Diarrhea or Insanity (both has pros and ♥♥♥♥ from events that boost cure progress, DNA cost, and cure progress being cut and slowed).
• Hemorrhagic Shock
  
  • Quite lethal speeding up the end which is important for that perfect score!

As you can see I didn't wait to see if all managed to get infected first but timed it so that all would die very shortly after receiving the message in the above image.

We should have more DNA so spend it on Insanity, Genetic Reshuffle, and/or more lethal symptoms to speed up the end as the end is now a guarantee for mankind.

By now we should be both use to reading the news and their dismal "Sorry, all is over and I have no one hold so here I am reporting the obvious" as well as the pleasure of knowing there is nothing that can stop the upcoming screen announcing your



Congratulations on defeating humanity with the Prion Disease and if you managed to follow this guide perfectly and random events were not as troublesome as they can sometimes be (some serious events slow things down allowing for the cure to jump or the time it took to kill off humanity lasting a bit too long), you should have a screen similar to mine below (though this game this has got to be my worst score out of 12 games of testing this guide).



With the speed of infection after Transmission and with the Combo Killer section I hope you guys managed to complete this guide without issues! I'd be happy to answer any questions anyone might have or take up requests (but know Neurax Worm and the Simian Flu are next on the list with Scenarios to follow). I'll get back to you as soon as I can! Thank you for reading :)

For those that don't follow my Weekly Contagion & Other Indies Stream & Giveaway I did one for Plague Inc: Evolved if you'd like to check it out!


Sorry but it does not let us embed a time-stamp. Plague Inc: Evolved portion starts at 5mins 10seconds.

Check out my other guides - http://steamoss.com/app/246620/discussions/0/43099721963116155/