Well, I still think that I've not played enough to judge this game, but.
Pathologic is a very strange game and I can't remember something similar. Devs created a wonderful and peculiar story, atmosphere, characters, idea, etc and did the great job combining these. Technical implementation is not the best, though.

That's priceless when you are a doctor, the one who should, who must stop the plague, but you also do need to survive, meaning you have a number of very questionable things to do.
You also go and trade water and things from trash bins with healthy people, despite the fact that you may have collected these in infected areas.
And the tension after the first days, it rises high and then slowly drops, just to rise again. A constant struggle.
But those are superficial things, Pathologic itself is about something very different.

The soundtrack is imo one of the most unique things you'll ever hear. Main menu theme is something. It's disturbing, as it should be, and gives the right atmosphere from the very start.

And please do not forget the coolest executors and tragedians.

"It is remarkable how this game resonates with so few people yet seemingly for every one that it does, it strikes them down to their very core" - some guy idk him