RACIONAL: Milhões de ratos são empregados anualmente em pesquisas e no ensino. A exata relação entre a idade dos ratos, comparada com a idade dos humanos ainda é assunto de discussão e controvérsias. OBJETIVO: É revisar a literatura, analisando a idade dos ratos em comparação com a idade dos homens. MÉTODOS: Foram revisadas as publicações existentes sobre o assunto contidas nas bases Medline/Pubmed, Scielo, Biblioteca Cochrane e Lilacs cruzando os descritores ratos, cirurgia experimental e fisiologia. RESULTADOS: Ratos desenvolvem rapidamente durante a infância e se tornam sexualmente maduros com cerca de seis semanas de idade, mas atingem a maturidade social cinco a seis meses mais tarde. Na idade adulta, a cada mês do animal é aproximadamente equivalente a 2,5 anos

humanos. Vários autores realizaram trabalhos experimentais em ratos e afirmaram existir correspondência de 30 dias de vida do homem para cada dia de vida do rato. CONCLUSÃO: As diferenças na anatomia, fisiologia, desenvolvimento e fenômenos biológicos devem ser levados em consideração quando são analisados os resultados de qualquer pesquisa em ratos em que a idade é um fator crucial. Cuidado especial é necessário ser tomado quando os estudos efetuados pretendem produzir correlação com a vida humana. Para isso, atenção especial é necessária para verificar a fase em dias do animal e sua correlação com os anos em humanos.

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The Black Rat, Rattus Rattus, was first described by Henrik Ahnberg in his 18th century work “A Dong’s guide to Dota”. An elusive and hardy creature, the rat excels at damaging structures and retreating at the first sign of danger, only to begin its attack anew once the threat has passed. Unlike many of his peers, Ahnberg greatly respected the rat, finding many of its features similar to his own. His love for the rat became so great that he soon left the world of men and descended into the sewers to live among the rats, eventually becoming their king.

They put me in a rubber room. They put me in a rubber room with rats! They put me in a rubber room with rubber rats!!! The rats drove me crazy. Crazy?...I was crazy once.They put me in a rubber room. They put me in a rubber room with rats! They put me in a rubber room with rubber rats!!! The rats drove me crazy. Crazy?...I was crazy once.They put me in a rubber room. They put me in a rubber room with rats! They put me in a rubber room with rubber rats!!! The rats drove me crazy. Crazy?...I was crazy once.They put me in a rubber room. They put me in a rubber room with rats! They put me in a rubber room with rubber rats!!! The rats drove me crazy. Crazy?...I was crazy once.They put me in a rubber room. They put me in a rubber room with rats! They put me in a rubber room with rubber rats!!! The rats drove me crazy. Crazy?...I was crazy once.They put me in a rubber room. They put me in a rubber room with rats! They put me in a rubber room with rubber rats!!!